Academic Faculty

Christopher L. Gentile, Ph.D.

Christopher L. Gentile, Ph.D.

Associate Professor

Gifford Building | (970) 491-7416 | christopher.gentile@colostate.edu


Research Support:

Ongoing Research Support
  • Mechanism: Boettcher Foundation Early Investigator Award
    Role: PI
    Dates: 07/2014-07/2017
    Title: Endoplasmic Reticulum Stress and the NLR Inflammasome in Obesity-Related Vascular Function
    Award: $225,000

Education:

Institution and Location Degree MM/YY Field of Study
Skidmore College B.S. 1995-1999 Physiology
University of Vermont None 2000-2001 Nutrition
University of Colorado at Boulder M.S. 2001-2004 Physiology
Virginia Tech Ph.D. 2004-2006 Physiology
Colorado State University Postdoc 2007-2010 Nutrition Biochemistry
Colorado State University Asst. Prof 2011- Nutrition Biochemistry

Professional Experience:

Positions
  • 1999-2000, Professional Research Assistant, Skidmore College, Dept. of Exercise Science
  • 2000-2001, Graduate Research Assistant, University of Vermont, Dept. of Medicine
  • 2003-2004, Professional Research Assistant, University of Colorado, Dept. of Integrative Physiology.
  • 2011-, Assistant Professor, Colorado State University, Dept. of Nutrition
Professional Memberships and Associations
  • Member, American Heart Association (AHA)
  • Member, American Diabetes Association (ADA)
  • Member, American Physiological Society (APS)
  • Member, The Obesity Society

Honors and Awards:

  • 2015 Recipient, NIH Loan Repayment Award
  • 2014 Boettcher Webb-Waring Early Investigator Biomedical Research Award
  • 2010 Recipient, NIH Career Development Award (K01, NIDDK)
  • 2009 Recipient, Postdoctoral Mentored Research Fellowship (F32, NIDDK), CSU
  • 2009- Manuscript Reviewer for several journals, including: Clin Lipidology, J of Nutr and Metab; MSSE

Publications (since 2010):

  • Cox-York KA, Sheflin AM, Foster MT, Gentile CL, Kahl A, Koch LG, Britton SL and Weir TL. Ovariectomoy results in differential shifts in gut microbiota in low versus high aerobic capacity rats. Physiological Reports 3 (8), 2015
  • Gentile CL, Weir TL, Cox-York KA, Wei Y, Wang D, Reese L, Moran G, Estrada A, Mulligan C, Pagliassotti MJ, and Foster MT. The role of visceral and subcutaneous adipose tissue fatty acid composition in pathophysiology associated with NAFLD. Adipocyte 4(2): 101-112, 2015
  • Sindler AE, Cox-York K, Reese L, Seals DR, Gentile CL. Oral nitrite administration improves endothelial function in diabetic mice. Diabetes and Vascular Research 12(3): 221-224, 2015
  • Kaplon RE, Chung E, Reese L, Cox-York K, Seals DR, Gentile CL. Activation of the unfolded protein response in vascular endothelial cells of nondiabetic obese adults. J Clin Endocrinol Metab. 98 (9): E1505-9, 2013
  • Arciero PJ, Ormsbee MJ, Gentile CL, Nindl BC, Brestoff JR, Ruby M. Increased protein intake and meal frequency reduces abdominal fat during energy balance and energy deficit. Obesity. 21 (7):1357-66, 2013
  • Nivala A, Reese L, Hemenway E, Frye MA, Gentile CL, Pagliassotti MJ. Fatty acid mediated endoplasmic reticulum stress in the liver in vivo: Differential response to the infusion of soybean and lard oil in rats. Metabolism. 62(5):753-60, 2013
  • Wang D, Wei Y, Frye MA, Gentile CL, Pagliassotti MJ. Saturated fatty acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. Journal of Nutrition and Metabolism. 2013:514206, 2013
  • Ellis F, Nivala A, Pfaffenbach KT, Gentile CL, Wang D, Wei Y, Pagliassotti MJ. C-reactive protein does not impair insulin suppression of glucose release in primary hepatocytes. Nutr Metab Cardiovasc Dis. 22: 115-119, 2012
  • Gentile CL, Nivala AM, Gonzales JC, Pfaffenbach KT, Wang D, Wei Y, Jiang H, Orlicky DJ, Petersen DR, Pagliassotti MJ, Maclean KN. Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease. American J of Physiology: Endo and Met. 301 (6):R1710-22, 2011
  • Gentile CL, Frye MA, Pagliassotti MJ. Endoplasmic Reticulum Stress and the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease. Antioxidants and Redox Signaling. 2011. 15(2):505-21. PMID: 21128705
  • Gentile CL, Frye MA, Pagliassotti MJ. Fatty Acids and Endoplasmic Reticulum Stress in Nonalocholic Fatty Liver Disease. Biofactors. 2011. 37(1): 8-16. PMID: 21328622
  • Gentile CL*, Nivala AM*, Gonzales JC, Pfaffenbach PT, Wang D, Wei Y, Jiang H, Petersen DR, Pagliassotti MJ, Maclean KN. Experimental evidence for therapeutic potential of taurine in the treatment of non-alcoholic fatty liver disease. AJP-Endocrinology and Metabolism. *authors contributed equally*
  • Ellis F, Nivala A, Pfaffenbach KT, Gentile CL, Wang D, Wei Y, Pagliassotti MJ. C-reactive protein does not impair insulin suppression of glucose release in primary hepatocytes. Nutr Metab Cardiovasc Dis. 2010.
  • Gentile CL, Wang D, Pfaffenbach KT, Cox R, Wei Y, Pagliassotti MJ. Fatty acids regulate CREBh via transcriptional Mechanisms that are dependent on proteasome activity and insulin. Mol Cell Biochem. 344(1-2): 99-107. 2010.
  • K.T. Pfaffenbach*, C.L. Gentile*, A.M. Nivala*, D. Wang, Y. Wei, M.J. Pagliassotti. Linking Endoplasmic Reticulum Stress to Cell Death in Hepatocytes: Roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. American Journal of Physiology: Endocrinology and Metabolism. 298(5): E1027-35. 2010. PMID: 20159858 *these authors contributed equally to this work